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X-ray investigation of the role of the mixed emulsifier in the structure formation in o/w creams
Authors:Magdolna Kónya  Imre Dékány  István Erõs
Institution:1.Department of Pharmaceutical Technology,University of Szeged,Szeged,Hungary;2.Department of Colloid Chemistry,University of Szeged,Szeged,Hungary;3.Budapest,Hungary
Abstract:The aim of this research work was to clarify the role of the mixed emulsifier in the structure formation and water binding mode in the case of o/w creams prepared with different surfactants. The swelling behavior of mixed emulsifiers was examined by means of direct investigation methods such as transmission electron microscopy (TEM) and X-ray diffraction. The detailed structure image of the creams was created with the help of the latter. The influence of the structure of the hydrophilic gel phase, and the structural changes during storage were studied with rheological methods. On the basis of the results, it can be stated that the investigated creams had different structures from those mentioned in the literature: surfactant did not create a mixed bilayer with the structure to furnish fatty amphiphile; instead, micelles were formed. These results correlated well with the results of the rheological tests.
Keywords:O/w creams  Microstructure  Mixed emulsifier  X-ray diffraction  Rheology
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