Microwave‐Assisted Synthesis of Substituted Dibenzo[b,f][1,4]thiazepines,Dibenzo[b,f][1,4]oxazepines,Benzothiazoles, and Benzimidazoles |
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| Authors: | Yu‐Chin Lin Ni‐Ching Li Yie‐Jia Cherng |
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| Institution: | Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung, Taiwan |
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| Abstract: | A highly efficient synthesis for possessing 7‐membered rings with two heteroatoms is described, using efficient microwave‐assisted one‐pot method to synthesize (substituted) dibenzob,f]1,4]thiazepines 1] and dibenzob,f]1,4]oxazepines 2] in high yields (up to 99%) by cyclocondensations of o‐aminothiophenol or o‐aminophenol with o‐halobenzaldehydes, o‐fluoroacetophenone, and o‐fluorobenzophenone. In the absence of base, o‐aminothiophenol reacted with o‐halobenzaldehydes to afford benzothiazoles. |
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