Synthesis and Structure Elucidation of New Regioisomeric 2‐Alkylamino‐6‐aryl‐8,9‐dihydropyrimido[4,5‐b][1,4]diazepin‐4(7H)‐ones |
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| Authors: | Braulio Insuasty Fabián Orozco Jairo Quiroga Rodrigo Abonía Manuel Nogueras Justo Cobo |
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| Affiliation: | 1. Heterocyclic Compounds Research Group, Department of Chemistry, Universidad del Valle, A. A., Cali, Colombia;2. Department of Chemistry, Universidad Nacional de Colombia, Bogotá, DC, Colombia;3. Department of Inorganic and Organic Chemistry, Universidad de Jaén, Jaén, Spain |
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| Abstract: | Novel 2‐Alkylamino‐6‐aryl‐8,9‐dihydropyrimido[4,5‐b][1,4]diazepin‐4(7H)‐ones 5a , 5b , 5c , 5d , 5e , 5f , 5g , 5h , 5i , 5j , 5k , 5l , 5m , 5n , 5o were prepared regioselectively by the reaction of 2‐alkylamino‐5,6‐diaminopyrimidin‐4(3H)‐ones 3a , 3b , 3c and dimethylamino propiophenones (Mannich bases) 4a , 4b , 4c , 4d , 4e , 4f . The combination of conventional heating and microwave irradiation approaches provided the possibility of working with both stable and sensitive diaminopyrimidines by controlling parameters such as reaction rates, temperature, and power of irradiation. All products were fully characterized by detailed NMR measurements. |
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