Three‐Component One‐Pot Synthesis of Indolo[3,4‐a]acridine Derivatives with High Regioselectivity under Catalyst‐Free Conditions |
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| Authors: | Mei‐Mei Zhang Wei Wang Xiang‐Shan Wang |
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| Affiliation: | 1. The Key Laboratory of Biotechnology on Medical Plant of Jiangsu Province, Jiangsu Normal University, Xuzhou, Jiangsu, People's Republic of China;2. School of Chemistry and Chemical Engineering, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University, Xuzhou, Jiangsu, People's Republic of China |
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| Abstract: | Three‐component reaction of aldehyde, 9‐ethyl‐9H‐carbazol‐3‐amine, and 5,5‐dimethyl cyclohexane‐1,3‐dione under catalyst‐free conditions in EtOH, regioselectivity gave corresponding indolo[3,4‐a]acridine rather than indolo[2,3‐b]acridine derivatives in high yields, which is confirmed by X‐ray diffraction analysis. |
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