Studies on the Reactivity of Amino‐1‐(6‐phenyl‐pyridazin‐3‐yl)‐1H‐pyrazole‐4‐carboxylic Acid Hydrazide Towards Some Reagents for Biological Evaluation |
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| Authors: | Ahmed H Shamroukh Aymn E Rashad Hatem S Ali Samir M Awad |
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| Institution: | 1. Photochemistry Department, National Research Center, Cairo, Egypt;2. Chemistry Department, Faculty of Science, Hail University, Saudi Arabia;3. Chemistry Department, Faculty of Science and Human Studies, Hurraiymla, Shaqra University, Saudi Arabia;4. Department of Food Science and Nutrition, College of Food Science and Agriculture, King Saud University, Saudi Arabia;5. Organic Chemistry Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt |
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| Abstract: | Novel 5‐amino‐1‐(6‐phenyl‐pyridazin‐3‐yl)‐1H‐pyrazole‐4‐carboxylic acid ethyl ester ( 2 ) was formed using (6‐phenyl‐pyridazin‐3‐yl)‐hydrazine ( 1 ) and ethyl(ethoxymethylene)cyanoacetate. The β‐enaminoester derivative 2 was in turn used as precursor for the preparation of 1‐(6‐phenyl‐pyridazin‐3‐yl)‐pyrazoles ( 3 , 4 , 7 , 8 , 9 , 10 , 11 , 12 , 15 , 16 ), 1‐(6‐phenyl‐pyridazin‐3‐yl)‐pyrazolo3,4‐d]pyrimidines ( 5 , 6 , 14 ) and 1‐(6‐phenyl‐pyridazin‐3‐yl)‐pyrazolo3,4‐d]1,2,3]triazine ( 13 ). The in vitro antimicrobial activity of the synthesized compounds was evaluated by measuring the inhibition zone diameters where some of them showed potent antimicrobial activity in compared with well‐known drugs (standards). |
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