Synthesis of 1,3-Bis[2-hydroxy-3-(3-methyl-5-oxo-2,5-dihydro-1-pyrazolyl)propyl)uracils |
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| Authors: | Krivonogov V. P. Sivkova G. A. Abdrakhmanov I. B. Kozlova G. G. Spirikhin L. V. Afzaletdinova N. G. |
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| Affiliation: | (1) Institute of Organic Chemistry, Ufa Scientific Center, Russian Academy of Sciences, Ufa, 450054, Russia |
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| Abstract: | ![]()
A reaction was studied of newly synthesized 1,3-bis(2-hydroxy-3-chloropropyl)uracil and 1,3-bis(2-hydroxy-3-chloropropyl)-6-methyluracil with hydrazine hydrate followed by treating the compounds formed with ethyl acetoacetate. The hydrazones obtained cyclized into pyrazolones in the presence of sodium methylate. |
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