In-vitro drug–drug interaction studies of diltiazem with floroquinolones |
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Authors: | Nighat Shafi Muhammad Saeed Arayne Najma Sultana |
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Institution: | 1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan;2. Faculty of Pharmacy, Federal Urdu University Arts, Science and Technology, Karachi, Pakistan;3. Department of Chemistry, University of Karachi, Karachi, Pakistan |
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Abstract: | Diltiazem is an established cardiovascular drug mainly used for the management of hypertension specifically for the angina pectoris. Fluoroquinolones are widely prescribed against the treatment of severe infections. In vitro relations of diltiazem with fluoroquinolones (ciprofloxacin, levofloxacin, norfloxacin, and ofloxacin) were examined using spectrophotometric and separation techniques, i.e., RP-HPLC. Diltiazem’s availabilities were observed to be predisposed highly in the presence of fluoroquinolones. To investigate the mechanism of interaction in a variety of dissolution environments, i.e., simulating body environments with regard to pH on these interactions has been studied. Moreover, complex of diltiazem–fluoroquinolones were prepared and elucidated through IR spectroscopy and confirmed by computational molecular modeling. |
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Keywords: | Diltiazem drug interactions fluoroquinolones HPLC and IR spectroscopy UV |
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