On the Synthesis of Some 2-Arylhydrazono-3-oxothieno[2,3-b]pyridines by Reaction of Nitrilimines with 2-Mercaptonicotinic Acid |
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| Authors: | Jalal A.?Zahra,Bassam Abu?Thaher,Mustafa M.?El-Abadelah,Hans-Hartwig?Otto mailto:ottohh@pharmazie.uni-greifswald.de" title=" ottohh@pharmazie.uni-greifswald.de" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author |
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| Affiliation: | (1) Chemistry Department, Faculty of Science, Jordan University, Amman, Jordan;(2) Chemistry Department, Faculty of Science, Islamic University of Gaza, Gaza Strip;(3) Department of Pharmaceutical/Medicinal Chemistry, University of Greifswald, 17487 Greifswald, Germany |
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| Abstract: | ![]()
Summary. Nitrilimines prepared from N-arylhydrazono chlorides reacted with 2-mercaptonicotinic acid yielding the corresponding addition products, 2-[(2-oxo-1-arylhydrazonopropan-1-yl)mercapto] nicotinic acids, which were treated with 1,1 -carbonyldiimidazole in THF affording by cyclocondensation the corresponding hitherto unknown 2-arylhydrazono-3-oxothieno[2,3-b]pyridines. |
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| Keywords: | . Arylacetonitrilimines 2-Mercaptonicotinic acid Cyclocondensation 3-Oxothieno [2,3-b]pyridines. |
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