Convenient synthesis of highly functionalized pyrazolines via mild, photoactivated 1,3-dipolar cycloaddition |
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| Authors: | Wang Yizhong Vera Claudia I Rivera Lin Qing |
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| Institution: | Department of Chemistry, University at Buffalo, State University of New York, Buffalo, New York 14260, USA. |
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| Abstract: | A mild, photoactivated 1,3-dipolar cycloaddition procedure was successfully developed for the synthesis of polysubstituted pyrazolines. This procedure involved the in situ generation of the reactive nitrile imine dipoles using a hand-held UV lamp at 302 nm, followed by spontaneous cycloaddition with a broad range of 1,3-dipolarophiles with excellent solvent compatibility, functional group tolerance, regioselectivity, and yield. |
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