Enantioselective total synthesis of (-)-erinacine B |
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| Authors: | Watanabe Hideaki Takano Masashi Umino Akinori Ito Toshiya Ishikawa Hiroyuki Nakada Masahisa |
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| Institution: | Department of Chemistry, Faculty of Science and Engineering, Waseda University, 3-4-1, Ohkubo, Shinjuku, Tokyo 169-8555, Japan. |
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| Abstract: | The first enantioselective total synthesis of (-)-erinacine B has been achieved. Our approach features convergent construction of the 5-6-7 tricyclic cyathane core system via chiral building blocks prepared using asymmetric catalysis developed by us and highly stereoselective construction of all stereogenic centers in the aglycon. reaction: see text]. |
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