| Poly（ethylene glycol）-supported Liquid-phase Parallel Synthesis of Di（aryloxyacetyl）thiosemicarbazides |
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| 作者姓名： | XiCunWANG JunKeWANG ZhengLI |
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| 作者单位： | CollegeofChemistryandChemicalEngineering,NorthwestNormalUniversity,Lanzhou730070 |
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| 摘 要： | An efficient poly(ethylene glycol) (PEG)-supported liquid-phase parallel approach to di(aryloxyacetyl)thiosemicarbazides is described. PEG-bound phenol reacted with chloroacetic acid to afford PEG-bound phenyloxyacetic acid, which was readily converted into corresponding phenyloxyacetyl chloride. Subsequent nucleophilic substitution with ammonium thiocyanate followed by addition of aryloxyacetic acid hydrazides gave PEG-bound di(aryloxyacetyl)thiosemicarbazides, which were easily cleaved to give the resulting library of 1-aryloxyacetyl-4-(4‘-methoxylcarbonylphenyloxyacetyl)thiosemicarbazides in good to high yield and high purity.
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| 关 键 词： | 二（芳香氧化乙酰）氨基硫脲 合成 聚乙烯乙二醇 液相反应 |
Poly(ethylene glycol)-supported Liquid-phase Parallel Synthesis of Di(aryloxyacetyl)thiosemicarbazides |
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| XiCunWANG JunKeWANG ZhengLI.Poly(ethylene glycol)-supported Liquid-phase Parallel Synthesis of Di(aryloxyacetyl)thiosemicarbazides[J].Chinese Chemical Letters,2004,15(6):635-638. |
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| Authors: | Xi Cun WANG Jun Ke WANG Zheng LI College of Chemistry and Chemical Engineering Northwest Normal University Lanzhou |
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| Institution: | Xi Cun WANG,Jun Ke WANG,Zheng LI College of Chemistry and Chemical Engineering,Northwest Normal University,Lanzhou 730070 |
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| Abstract: | An efficient poly(ethylene glycol) (PEG)-supported liquid-phase parallel approach to di(aryloxyacetyl)thiosemicarbazides is described. PEG-bound phenol reacted with chloroacetic acid to afford PEG-bound phenyloxyacetic acid, which was readily converted into corresponding phenyloxyacetyl chloride. Subsequent nucleophilic substitution with ammonium thiocyanate followed by addition of aryloxyacetic acid hydrazides gave PEG-bound di(aryloxyacetyl)thiosemi-carbazides, which were easily cleaved to give the resulting library of 1-aryloxyacetyl-4-(4'-methoxylcarbonylphenyloxyacetyl)thiosemicarbazides in good to high yield and high purity. |
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| Keywords: | Liquid-phase synthesis PEG di(aryloxyacetyl)thiosemicarbazide |
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