Studying the emergence of invasiveness in tumours using game theory |
| |
Authors: | D Basanta H Hatzikirou A Deutsch |
| |
Institution: | 1.Zentrum für Informationsdienste und Hochleistungsrechnen, Technische Universit?t Dresden,Dresden,Germany |
| |
Abstract: | Tumour cells have to acquire a number of capabilities if a neoplasm is to become a cancer. One of these key capabilities is
increased motility which is needed for invasion of other tissues and metastasis. This paper presents a qualitative mathematical
model based on game theory and computer simulations using cellular automata. With this model we study the circumstances under
which mutations that confer increased motility to cells can spread through a tumour made of rapidly proliferating cells. The
analysis suggests therapies that could help prevent the progression towards malignancy and invasiveness of benign tumours. |
| |
Keywords: | PACS" target="_blank">PACS 87 17 Aa Modeling computer simulation of cell processes 87 19 xj Cancer 87 23 Kg Dynamics of evolution |
本文献已被 SpringerLink 等数据库收录! |