A new and efficient strategy for the synthesis of podophyllotoxin and its analogues |
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| Authors: | Wu Yingming Zhang Hongbin Zhao Yuanhong Zhao Jingfeng Chen Jingbo Li Liang |
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| Affiliation: | Key Laboratory of Medicinal Chemistry for Natural Resource (Yunnan University), Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, Yunnan, PR China. |
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| Abstract: | [structure: see text]. An efficient and stereoselective strategy for the total synthesis of podophyllotoxin was developed. This route leads to podophyllotoxin 1 in only 12 steps with 29% overall yield. A notable feature of this synthetic strategy is the use of the cascade addition-alkylation to ensure the key C1-C2 stereochemistry that is pivotal for the synthesis of podophyllotoxin. |
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