Increasing synthetic efficiency via direct C-H functionalization: formal synthesis of an inhibitor of botulinum neurotoxin |
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| Authors: | Potavathri Shathaverdhan Kantak Abhishek DeBoef Brenton |
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| Affiliation: | Department of Chemistry, University of Rhode Island, 51 Lower College Road, Kingston, RI 02881, USA. |
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| Abstract: | ![]()
A new and efficient scheme for the synthesis of one of the best known inhibitors of botulinum neurotoxin serotype A (BoNTA) is reported herein. The synthetic route involves two palladium-catalyzed C-H functionalization reactions, formally activating three C-H bonds. |
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