Low-Flammable Parahydrogen-Polarized MRI Contrast Agents |
| |
| Authors: | Dr Baptiste Joalland Nuwandi M Ariyasingha Hassan R Younes Shiraz Nantogma Dr Oleg G Salnikov Dr Nikita V Chukanov Dr Kirill V Kovtunov Prof Igor V Koptyug Prof Juri G Gelovani Prof Eduard Y Chekmenev |
| |
| Institution: | 1. Department of Chemistry, Integrative Biosciences (Ibio), Karmanos Cancer Institute (KCI), Wayne State University, Detroit, Michigan, 48202 USA;2. International Tomography Center SB RAS, Institutskaya St. 3A, 630090 Novosibirsk, Russia |
| |
| Abstract: | Many MRI contrast agents formed with the parahydrogen-induced polarization (PHIP) technique exhibit biocompatible profiles. In the context of respiratory imaging with inhalable molecular contrast agents, the development of nonflammable contrast agents would nonetheless be highly beneficial for the biomedical translation of this sensitive, high-throughput and affordable hyperpolarization technique. To this end, we assess the hydrogenation kinetics, the polarization levels and the lifetimes of PHIP hyperpolarized products (acids, ethers and esters) at various degrees of fluorine substitution. The results highlight important trends as a function of molecular structure that are instrumental for the design of new, safe contrast agents for in vivo imaging applications of the PHIP technique, with an emphasis on the highly volatile group of ethers used as inhalable anesthetics. |
| |
| Keywords: | flammability fluorine hyperpolarization inhalable anesthetics parahydrogen |
|
|
