The Photosensitizing Efficacy of Micelles Containing a Porphyrinic Photosensitizer and KI against Resistant Melanoma Cells |
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| Authors: | Dr Kelly A D F Castro Letícia D Costa Juliana A Prandini Dr Juliana C Biazzotto Prof Dr Augusto C Tomé Prof Dr Michael R Hamblin Prof Dr Maria da Graça P M S Neves Prof Dr M Amparo F Faustino Prof Dr Roberto S da Silva |
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| Institution: | 1. Department of Physics and Chemistry, Faculty of, Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil;2. LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Aveiro, Portugal;3. Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, 2028 South Africa |
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| Abstract: | Photodynamic therapy (PDT) is a promising alternative to overcome the resistance of melanoma to conventional therapies. Currently applied photosensitizers (PS) are often based on tetrapyrrolic macrocycles like porphyrins. Unfortunately, in some cases the use of this type of derivative is limited due to their poor solubility in the biological environment. Feasible approaches to surpass this drawback are based on lipid formulations. Besides that, and inspired in the efficacy of potassium iodide (KI) for antimicrobial photodynamic therapy (aPDT), the combined effect of singlet oxygen (1O2) with KI was assessed in this work, as an alternative strategy to potentiate the effect of PDT against resistant melanoma cells. |
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| Keywords: | iodine melanoma PDT porphyrin singlet oxygen |
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