Polysaccharide Chemistry in Drug Delivery,Endocrinology, and Vaccines |
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Authors: | Aimen Khalid Dr Asim-ur-Rehman Dr Naveed Ahmed Iqra Chaudhery Dr Meneerah A Al-Jafary Prof Ebtesam Abdullah Al-Suhaimi Dr Mohamad Tarhini Dr Noureddine Lebaz Dr Abdelhamid Elaissari |
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Institution: | 1. Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, 45320 Islamabad, Pakistan;2. Biology Department, College of Science, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, 31441 Dammam, Saudi Arabia;3. Univ Lyon, University Claude Bernard Lyon-1, CNRS, ISA-UMR 5280, 69622 Villeurbanne, France;4. Univ Lyon, University Claude Bernard Lyon-1, CNRS, LAGEPP-UMR 5007, 69100 Villeurbanne, France |
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Abstract: | Polysaccharides, due to their outstanding properties, have attracted the attention of researchers, working in the biomedical field and especially of those working in drug delivery. Modified/functionalized polysaccharides further increase the importance for various applications. Delivery of therapeutics for diverse ailments in different endocrine glands and hormones safely, is a focal point of researchers working in the field. Among the routes followed, the transdermal route is preferred due to non-exposure of active moieties to the harsh gastric environment and first-pass metabolism. This review starts with the overview of polysaccharides used for the delivery of various therapeutic agents. Advantages of polysaccharides used in the transdermal route are addressed in detail. Types of polysaccharides will be elaborated through examples, and in this context, special emphasis will be on the polysaccharides being used for synthesis of the membranes/films. Techniques employed for their modification to design novel carriers for therapeutics delivery will also be discussed. The review will end with a brief discussion on recent developments and future perspectives for delivery of therapeutic agents, and vaccine development. |
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Keywords: | Functionalization membranes/films Natural Polysaccharides polysaccharides in Endocrinology polysaccharides in Vaccines |
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