The dynamic chromatographic behavior of tri-o-thymotide on HPLC chiral stationary phases |
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| Authors: | Mortera Stefano Levi Sabia Rocchina Pierini Marco Gasparrini Francesco Villani Claudio |
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| Affiliation: | Sapienza Università di Roma, Dipartimento di Chimica e Tecnologie del Farmaco, P.le A. Moro 5, 00185, Rome, Italy. |
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| Abstract: | ![]()
The interconverting stereoisomers of tri-o-thymotide have been separated by HPLC on chiral stationary phases and the temperature dependence of the dynamic chromatographic patterns has been interpreted in terms of exchange between enantiomeric propeller and helical conformations. Computed low energy structures and CD spectra were used in absolute configuration assignment. |
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