Highly efficient synthesis of N-confused meso-tetraspirocyclohexyl calix[4]pyrrole using Brønsted acidic ionic liquids as catalysts |
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Authors: | Bhaskar GargYong-Chien Ling |
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Institution: | Department of Chemistry, National Tsing Hua University, 101, Section 2, Kuang-Fu Road, Hsinchu 30013, Taiwan, ROC |
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Abstract: | An efficient, green and novel protocol is described for high yield synthesis of N-confused meso-tetraspirocyclohexyl calix4]pyrrole. In aqueous solution, the condensation of pyrrole and cyclohexanone in the presence of Brønsted acidic ionic liquid catalysts afforded N-confused calix4]pyrrole in up to 62.5% yield which represents a ∼threefold yield improvement over existing protocol and makes significant quantity of N-confused calix4]pyrrole readily available. |
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Keywords: | Brø nsted acidic ionic liquids N-confused calix[4]pyrrole Catalysis Pyrrolidonium Green chemistry |
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