Enantioselective synthesis of functionalized fluorinated dihydropyrano [2,3-c]pyrazoles catalyzed by a simple hi functional diaminocyclohexane-thiourea |
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| Authors: | Hong-Fei Zhang Zheng-Qing Ye Gang Zhao |
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| Institution: | Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China |
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| Abstract: | Enantioselective synthesis of functionalized fluorinated dihydropyrano2,3-c]pyrazoles has been achieved via a diaminocyclohexane-thiourea catalyzed cascade Michael addition and Thorpe-Ziegler type cyciization in high yields(up to 98%) with moderate to good enantioselectivity(up to 90% ee). |
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| Keywords: | Trifluoromethyl Pyrazoles Cyclization Organocatalysis |
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