| An improved synthesis of(lS,4S)-2-oxa-5-azabicyclo[2.2.1]heptane |
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| 引用本文： | Dong-Feng Zhang,Peng Li,Zi-Yun Lin,Hai-Hong Huang. An improved synthesis of(lS,4S)-2-oxa-5-azabicyclo[2.2.1]heptane[J]. 中国化学快报, 2014, 25(3): 479-481. DOI: 10.1016/j.cclet.2013.12.006 |
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| 作者姓名： | Dong-Feng Zhang Peng Li Zi-Yun Lin Hai-Hong Huang |
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| 作者单位： | Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100050, China |
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| 摘 要： | An improved and efficient method for synthesis of(lS,4S)-2-oxa-5-azabicyclo[2.2.1]heptane(1) from trans-4-hydroxy-L-proline was developed. Using benzyloxycarbonyl(Cbz) as protection group of amine, the reactions were inmild conditions, and the title compound 1 was accomplished in six steps in overall yield of 70%.
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| 关 键 词： | Synthesis trans--Hydroxy-L-proline Bridged morpholine |
| 收稿时间： | 2013-09-04 |
An improved synthesis of （IS,4S）-2-oxa-5-azabicyclo[2.2.1]heptane |
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| 《Chinese Chemical Letters》. An improved synthesis of （IS,4S）-2-oxa-5-azabicyclo[2.2.1]heptane[J]. Chinese Chemical Letters, 2014, 25(3): 479-481. DOI: 10.1016/j.cclet.2013.12.006 |
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| Authors: | 《Chinese Chemical Letters》 |
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| Affiliation: | Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100050, China |
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| Abstract: | An improved and efficient method for synthesis of(lS,4S)-2-oxa-5-azabicyclo[2.2.1]heptane(1) from trans-4-hydroxy-L-proline was developed. Using benzyloxycarbonyl(Cbz) as protection group of amine, the reactions were inmild conditions, and the title compound 1 was accomplished in six steps in overall yield of 70%. |
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| Keywords: | Synthesistrans-4-Hydroxy-L-prolineBridged morpholine |
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