Synthesis and antibacterial activity of ethyl 2-amino-6-methyl-5-oxo- 4-aryl-5,6-dihydro-4H-pyrano[3,2-c]quinoline-3-carboxylate |
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| Authors: | Sakineh Asghari Samaneh Ramezani Mojtaba Mohseni |
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| Institution: | a Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar 47416-95447, Iran;
b Nano and Biotechnology Research Group, University of Mazandaran, Babolsar 47416-95447, Iran;
c Department of Microbiology, Faculty of Sciences, University of Mazandaran, Babolsar 47416-95447, Iran |
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| Abstract: | The three-component reaction of 4-hydroxy-1-methyl-2(1H)-quinolinone, aromatic aldehydes and ethyl cyanoacetate was carried out in the presence of a catalytic amount of 4-dimethyl aminopyridine(DMAP) in aqueous ethanol. The reactions result in the formation of pyranoquinoline derivatives in excellent yields. Antibacterial activity has been evaluated against Gram positive and Gram negative bacteria for some of the synthesized compounds. The results indicated that these compounds are moderately effective against bacterial growth and their effectiveness is highest against Pseudomonas aeruginosa. |
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| Keywords: | Three-component reactionPyranoquinoline4-Dimethyl aminopyridine （DMAP）Antibacterial activity |
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