| [Ru(phen)2dppz]2+二聚及对DNA键合性质的影响 |
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| 引用本文： | 聂晶,韩美娇,王科志. [Ru(phen)2dppz]2+二聚及对DNA键合性质的影响[J]. 高等学校化学学报, 2007, 28(10): 1833-1835 |
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| 作者姓名： | 聂晶 韩美娇 王科志 |
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| 作者单位： | 北京师范大学化学学院,北京,100875 |
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| 基金项目： | 国家自然科学基金 , 北京市自然科学基金 , 教育部高等学校博士学科点专项科研基金 , 北京师范大学校科研和教改项目 |
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| 摘 要： | 研究发现, [Ru(phen)2dppz]2+表现出非常强的自聚合倾向, 并显著影响DNA的键合性质, 有关方面的研究应引起科研工作者的足够重视.
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| 关 键 词： | 钌 邻菲啰啉 DNA 光开关 二聚 |
| 文章编号： | 0251-0790（2007）10-1833-03 |
| 收稿时间： | 2007-04-23 |
| 修稿时间： | 2007-04-23 |
Effects of the Dimerization of [ Ru(Phen)2dppz ] 2+ on the Calf Thymus Binding Properties |
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| NIE Jing,HAN Mei-Jiao,WANG Ke-Zhi. Effects of the Dimerization of [ Ru(Phen)2dppz ] 2+ on the Calf Thymus Binding Properties[J]. Chemical Research In Chinese Universities, 2007, 28(10): 1833-1835 |
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| Authors: | NIE Jing HAN Mei-Jiao WANG Ke-Zhi |
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| Affiliation: | College of Chemistry, Beijing Normal University, Beijing 100875, China |
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| Abstract: | The dimerization of a well-known DNA light-switch [Ru(phen)2dppz]2+(phen=1,10-phenanthroline, dppz=dipyrido[3,2-a:2',3'-c]phenazine), and its effect on calf thymus binding properties were studied by UV-Vis and emission spectroscopy in Tris-HCl buffered 50 mmol/L NaCl(pH=7.1). The results show that the complex has a strong tendency to dimerize with a dimerization constant of (1.8±0.3)×106 L/mol at the same order of magnitude as the DNA binding constant of (6.0±1.2)×106 L/mol for the Ru(Ⅱ) complex dimer, but one order of magnitude less than (4.9±1.5)×107 L/mol for the Ru(Ⅱ) complex monomer. This study has provided insight into a fundamental but important issue that should be taken into account for the DNA binding studies. |
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| Keywords: | Ruthenium Phenanthroline DNA Light switch Dimerization |
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