Palladium-catalyzed ortho-arylation of benzamides via direct sp(2) C-H bond activation |
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| Authors: | Li Dan-Dan Yuan Ting-Ting Wang Guan-Wu |
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| Institution: | CAS Key Laboratory of Soft Matter Chemistry, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, PR China. |
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| Abstract: | The palladium-catalyzed ortho-arylation of benzamides by aryl iodides has been demonstrated with the simplest amide CONH(2) as a directing group for the first time. This protocol can be applied to various benzamides and aryl iodides with both electron-donating and electron-withdrawing groups. In addition, the synthesized biphenyl-2-carboxamides can be further transformed to other biphenyl derivatives such as nitriles, carboxylic acids, carbamates, and amines. |
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