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| 含氟β-氨基酸及其衍生物的合成进展 | |
| 引用本文： | 彭荣达,郝健. 含氟β-氨基酸及其衍生物的合成进展[J]. 有机化学, 2005, 25(5): 485-496 |
| 作者姓名： | 彭荣达 郝健 |
| 作者单位： | 1. 上海大学化学系,上海,200436 2. 上海大学化学系,上海,200436;中国科学院上海有机化学研究所,有机氟化学重点实验室,上海,200032 |
| 基金项目： | 中国科学院资助项目，上海市教委资助项目，教育部留学回国人员科研启动基金 |
| 摘 要： | 含氟β-氨基酸及其衍生物具有特殊的生理活性, 其合成方法的研究近年来受到广泛关注. 以直接氟化法和间接氟化法分类, 概述了含氟β-氨基酸及其衍生物的合成方法及最新研究进展, 对一些已知化合物的生理活性及药用价值作了初步归纳. |
| 关 键 词： | 含氟β-氨基酸 合成砌块 合成 进展 生物活性 |
| 收稿时间： | 2004-07-12 |
| 修稿时间： | 2004-10-29 |
Recent Development in the Synthesis of Fluorinated-Amino Acids and Their Derivatives |
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| PENG Rong-Da,HAO Jian. Recent Development in the Synthesis of Fluorinated-Amino Acids and Their Derivatives[J]. Chinese Journal of Organic Chemistry, 2005, 25(5): 485-496 | |
| Authors: | PENG Rong-Da HAO Jian |
| Affiliation: | (Department of Chemistry, Shanghai University, Shanghai 200436)(Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032) |
| Abstract: | Fluorinated β-amino acids and their derivatives with specific bioactivities have been attracting great attention. This review briefly summarized the recent development in the methodologies for the synthesis of biologically important fluorinated β-amino acids and their derivatives with classification by the ways of the direct and indirect fluorination respectively. |
| Keywords: | fluorinated β-amino acid building block synthesis development bioactivity |
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