Dioxygen-Triggered β-Hydroxysulfonylation of Terminal Olefins Controlled by DABCO |
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| Authors: | Prof Dr Hang Gong Yuhan Zhao Xia Meng Prof Dr Changqun Cai |
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| Institution: | 1. College of Chemistry and, Chemical Engineering, Yunnan Normal University, Kunming, 650500 P. R. China;2. The key Laboratory for Green Organic Synthesis and Application of Hunan Province, Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan, 411105 P. R. China |
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| Abstract: | A dioxygen-triggered selectively difunctionalization of olefins to achieve β-hydroxysulfones has been developed. Particularly, the mechanism of this reaction can be controlled by DABCO, which act as a single electron transfer reagent, to selectively obtain ketosulfone or hydroxysulfone. The reaction was conducted in a clean, safe, mild, and catalyst-free conditions. Moreover, as a proof-of-concept, two bioactive molecules were synthesized easily using this method. |
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| Keywords: | DABCO dioxygen-triggered reaction β-hydroxysulfones metal-free reaction terminal olefins |
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