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Blue-LED Synthesis of Pummerer's Ketones by Peroxidase-Lignin-Catalyzed Oxidative Coupling of Substituted Phenols |
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| Authors: | Dr. Davide Piccinino Dr. Natalia Ceccotti Vlas Dr. Sofia Gabellone Dr. Eliana Capecchi Prof. Raffaele Saladino |
| Affiliation: | 1. Department of Biological and Ecological Sciences, University of Tuscia, Largo dell'Università, snc, 01100 Viterbo, VT, Itlay;2. Istituto Romagnolo per lo Studio dei Tumori “Dino Amadori” –, IRST IRCCS, Via Piero Maroncelli, 40, 47014 Meldola, FC, Italy |
| Abstract: | Pummerer's ketones resembling the tricyclic scaffold of bioactive natural substances were synthesized by blue-LED driven Horseradish Peroxidase oxidative coupling of substituted phenols in 2-methyltetrahydrofuran by using meso-tetraphenylporphyrin as photosensitizer and dioxygen as primary oxidant. The application of functionalized lignin nanoparticles as a renewable and efficient platform for the immobilization of the enzyme extended the effectiveness of the overall process to heterogeneous catalysis under buffer limiting conditions. |
| Keywords: | Blue-LED photons Lignin nanoparticles Peroxidase Photo-biocatalysis Pummerer's ketones |