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Iridium-Catalyzed C5-Regioselective Esterification of Dienyl Alcohols with Carboxylic Acids |
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| Authors: | Jiadong Chen Yulu Zhang Prof. Dr. Shengbiao Tang Prof. Dr. Ying Shao Prof. Dr. Jiangtao Sun |
| Affiliation: | 1. Jiangsu Key Laboratory of Advanced, Catalytic Materials & Technology, School of Petrochemical Engineering, Changzhou University, 1 Gehu Road, 213164 Changzhou, P. R. China These authors contributed equally to this work.;2. Jiangsu Key Laboratory of Advanced, Catalytic Materials & Technology, School of Petrochemical Engineering, Changzhou University, 1 Gehu Road, 213164 Changzhou, P. R. China |
| Abstract: | One-step process for the preparation of a 1,3-dienyl-5-ester motif from readily available substrate remains a challenging work in organic synthesis. We herein report the first example of C5-regioselective esterification of unactivated dienyl alcohols, using free carboxylic acids as nucleophiles under mild conditions, providing a series of 1,3-dienyl-5-ester compounds in excellent regioselectivity and E-selectivity. |
| Keywords: | allylic substitution carboxylic acids esterification iridium regioselective |