| 高效液相色谱法分离测定洛伐他汀及其开环酸 |
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| 引用本文： | 杜方鸣,于燕梅,李洲,林仙武.高效液相色谱法分离测定洛伐他汀及其开环酸[J].分析测试技术与仪器,2003,9(2):95-97. |
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| 作者姓名： | 杜方鸣 于燕梅 李洲 林仙武 |
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| 作者单位： | 1. 清华大学化学工程系,北京,100084
2. 浙江瑞邦大药厂,浙江,温州,325027 |
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| 摘 要： | 改进了洛伐他汀的分析方法，以甲醇：水＝80：20为流动相，采用紫外检测器检测，使用C4色谱柱定性、定量分析了洛伐他汀及洛伐他汀羟基酸，并得出了相关方程．实验证明，采用新的色谱条件可在有效地分析洛伐他汀及其开环酸的基础上，节约分析成本．
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| 关 键 词： | 高效液相色谱法 分离 测定 洛伐他汀 开环酸 降血脂药物 |
| 文章编号： | 1006-3757(2003)02-0095-03 |
| 收稿时间： | 2003/3/24 0:00:00 |
| 修稿时间： | 2003年3月24日 |
Determination of Lovastatin and Lovastatin Acid by High Performance Liquid Chromatography |
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| DU Fang-ming,YU Yan-mei,LI Zhou and LIN Xian-wu.Determination of Lovastatin and Lovastatin Acid by High Performance Liquid Chromatography[J].Analysis and Testing Technology and Instruments,2003,9(2):95-97. |
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| Authors: | DU Fang-ming YU Yan-mei LI Zhou and LIN Xian-wu |
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| Institution: | Department of Chemical Engineering, Tsinghua University, Beijing 100084, China;Department of Chemical Engineering, Tsinghua University, Beijing 100084, China;Department of Chemical Engineering, Tsinghua University, Beijing 100084, China;Zhejiang Ruibang Pharmaceutical Factory, Wenzhou 325027, China |
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| Abstract: | An improved reverse phase HPLC method has been established to determine lovastatin and lovastatin acid. The C4 column and the UV detector were applied, and methanol-water(80:20) was used as the mobile phase. The experimental results show that the improved chromatographic conditions can be used to analyze the lovastatin and lovastatin acid effectively and economically. |
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| Keywords: | lovastatin lovastatin acid HPLC |
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