细茎石斛多糖的降血糖活性作用

观察细茎石斛 ( Dendrobium moniliforme ( L .) Sw .)多糖对多种模型小鼠血糖水平的影响 ,探讨其降血糖作 用机理 .采用昆明种小鼠分组 ,分别以细茎石斛多糖 (100 mg· kg - 1 、200 mg· kg - 1 )、格列苯脲片 (50 mg· kg - 1 )、盐 酸苯乙双胍 (50 mg· kg - 1 )或生理盐水灌胃 ,测定各正常小鼠、肾上腺素性糖尿病和四氧嘧啶性糖尿病小鼠的血糖 水平 .结果 100 mg · kg - 1 、200 mg · kg - 1 两个剂量的细茎石斛多糖均能显著降低肾上腺素、四氧嘧啶引起的糖尿病 小鼠的血糖水平 (p < 0. 01) ,提高四氧嘧啶性糖尿病小鼠的葡萄糖耐量 (p < 0. 01),但对正常小鼠的血糖水平无影 响 .细茎石斛多糖具有明显的降血糖作用 ,是一种值得开发利用的降糖植物多糖.

Hypoglycemic effect of the polysaccharide from Dendrobium moniliforme(L.)Sw

To observe the hypoglycemic effect of polysaccharides from Dendrobium moniliforme (L.) Sw. ( DM P) on experimental diabetic mice and discuss the anti - hyperglycemic mechanism , mice were divided into different groups and each group was given DM P (100 and 200 mg · kg - 1 , ig ), glybenclamide ( 50 mg · kg - 1 , ig ), phenformin ( 50 mg· kg - 1 , ig) or normal saline, respectively. The levels of serum glucose were determined in normal control groups and diabetic mice groups induced by adrenalin( 20 mg· kg - 1 , ip) or alloxan( 200 mg· kg - 1 , ip). Both doses of DM P (100 and 200 mg · kg - 1 , ig ) could remarkably decrease the serum glucose in adrenalin and alloxan induced diabetic mice ( p < 0. 01) and increase glucose tolerance . On the other hand , it was found that DMP has no signifi- cant influence on the serum glucose level of normal mice. DMP has significant effects of hypoglycemic action in dia- betic mice. It is worthy to be utilized to develop medicines for diabetes.