| 新型1,8-萘酰亚胺类化合物与DNA相互作用的研究 |
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| 引用本文： | 赵婷,张军波,杨婷婷,梁淑彩,邱国福,胡先明.新型1,8-萘酰亚胺类化合物与DNA相互作用的研究[J].分析科学学报,2007,23(4):413-416. |
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| 作者姓名： | 赵婷 张军波 杨婷婷 梁淑彩 邱国福 胡先明 |
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| 作者单位： | 武汉大学药学院,武汉,430072 |
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| 摘 要： | 用荧光光谱、紫外光谱、粘度法对两种新型1,8-萘酰亚胺类化合物N-羟乙基-3-硝基-4-溴-1,8-萘酰亚胺(B)和N-羟乙基-4-羟乙基-3-硝基-1,8-萘酰亚胺(N)与DNA的相互作用进行了研究,考察和比较了它们与DNA的作用模式和强度,求出了两种化合物的嵌入常数。结果表明,化合物N和B主要以插入方式与DNA作用,且化合物N与DNA的作用强于化合物B。
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| 关 键 词： | 1 8-萘酰亚胺化合物 DNA 相互作用 |
| 文章编号： | 1006-6144（2007）04-0413-04 |
| 修稿时间： | 2006-09-19 |
Interaction of Two New 1,8-Naphthalimide Compounds with DNA |
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| ZHAO Ting,ZHANG Jun-bo,YANG Ting-ting,LIANG Shu-cai,QIU Guo-fu,HU Xian-ming.Interaction of Two New 1,8-Naphthalimide Compounds with DNA[J].Journal of Analytical Science,2007,23(4):413-416. |
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| Authors: | ZHAO Ting ZHANG Jun-bo YANG Ting-ting LIANG Shu-cai QIU Guo-fu HU Xian-ming |
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| Institution: | College of Pharmacy, Wuhan University, Wuhan 430072 |
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| Abstract: | In this paper,the interactions between two new 1,8-Naphthalimide compounds,namely 4-bromine-N-hydroxylethyl-3-nitro-1,8-Naphthalimide(Compound B) and 4-hydroxylethyl-N-hydroxylethyl-3-nitro-1,8-naphthalimide(Compound N),respectively,with DNA were studied by absorption,fluorescence spectral and viscometric experiments.The results of the experiments indicated that both N and B could intercalate into the stack base pairs of DNA and N had higher binding capacity to DNA comparing with B. |
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| Keywords: | 1 8-Naphthalimides DNA Interactions |
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