Two new sesquiterpene lactones from Sonchus arvensis |
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| Authors: | Zhengxiang Xia Jincheng Yao Jingyu Liang |
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| Institution: | (1) Department of Chemistry, School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. China;(2) Hunan Center for Drug Reevalution and ADR Monitoring, Changsha, P. R. China;(3) Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, 210009, P. R. China; |
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| Abstract: | Two new sesquiterpene lactones, 1β,15-diacetoxy-5,7α,6,11β(H)-eudesm-3,4-en-6,12-olide (1) and 1β-hydroxy-3,4-en-15-O-β-glucopyranosyl-5,7α,6,11β(H)-eudesman-6,12-olide (2), were isolated from Sonchus arvensis L. (Asteraceae), together with ten known compounds. Their structures were elucidated through spectroscopic and chemical methods.
All these known compounds except oleanolic acid (11) were isolated from the genus Sonchus for the first time. Selected new compounds were evaluated for antibacterial activity; unfortunately, they showed weak or
no activities against Streptococcus mutans ATCC 25175. |
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