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Hydrogels Incorporating GdDOTA: Towards Highly Efficient Dual T(1) /T(2) MRI Contrast Agents |
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| Authors: | Thomas Courant Valérie Gaëlle Roullin Cyril Cadiou Maïté Callewaert Marie Christine Andry Christophe Portefaix Christine Hoeffel Marie Christine de Goltstein Marc Port Sophie Laurent Luce Vander Elst Robert Muller Michaël Molinari Françoise Chuburu |
| Affiliation: | Institut de Chimie Moléculaire de Reims, CNRS UMR 7312, Université de Reims Champagne Ardenne, UFR de Pharmacie, 51 rue Cognacq-Jay, 51100 Reims (France); Institut de Chimie Moléculaire de Reims, CNRS UMR 7312, Université de Reims Champagne Ardenne, BP 1039, 51687 Reims Cedex 2 (France). |
| Abstract: | Do not tumble dry: Gadolinium-DOTA encapsulated into polysaccharide nanoparticles (GdDOTA?NPs) exhibited high relaxivity (r(1) =101.7?s(-1) mM(-1) per Gd(3+) ion at 37?°C and 20?MHz). This high relaxation rate is due to efficient Gd loading, reduced tumbling of the Gd complex, and the hydrogel nature of the nanoparticles. The efficacy of the nanoparticles as a T(1) /T(2) dual-mode contrast agent was studied in C6 cells. |
| Keywords: | T1/T2 contrast agents gadolinium gels imaging agents nanoparticles |
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