Determination of Simvastatin in tablet formulations by derivative UV spectrophotometry |
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| Authors: | J. S. Millership J. Chin |
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| Affiliation: | (1) University of Michigan, and Department of Pharmacy Services, University of Michigan Hospitals and Health Centers, Ann Arbor, MI, USA;(2) University of Michigan, and Director, Drug Information and Investigational Drug Services, Department of Pharmacy Services, University of Michigan Health System, Ann Arbor, MI, USA; |
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| Abstract: | ![]()
An investigation of UV spectroscopic methods, i.e. absorbance, 1st and 2nd derivative spectra for the determination of simvastatin in tablet formulations has been undertaken. This work investigated the possible difficulties that might arise due to the presence of UV absorbing excipients and likely presence of degradation products in such assays. We have demonstrated that the presence of ascorbic acid as an excipient causes interference with simple absorbance measurements leading to a gross over-determination of the simvastatin. 1st and 2nd derivative methods appear to eliminate this problem. We have also shown that the degradation product of simvastatin, i.e. simvastatin β-hydroxy acid, having an almost identical spectrum to the parent drug, may cause problems in the UV spectroscopic determination of the drug in degraded samples. |
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