Identification of Apigenin Metabolites in Rat Liver Perfusate by Column Switching High Performance Liquid Chromatography/Electrospray Ionization Mass Spectrometry |
| |
| Authors: | Jean-Philippe Basly Anséline Gradolatto Caroline Teyssier Naric Chantal Canivenc-Lavier |
| |
| Affiliation: | (1) UPRES EA 1085 “Biomolécules et Cibles Cellulaires Tumorales”, UFR de Pharmacie, F-87025 Limoges, France, FR;(2) UMR 938 “Toxicologie Alimentaire”, INRA, BP 86510, F-21065 Dijon, France, FR |
| |
| Abstract: | ![]()
Summary. A selective column switching high performance liquid chromatographic method has been used for the simultaneous determination of apigenin and metabolites in rat liver perfusate. This new method clearly separated apigenin and the metabolites with high resolution. The structures of metabolites were proposed based on selective ion recording and full scan analysis by electrospray ionization mass spectrometry. Corresponding author. E-mail: basly@pharma.unilim.fr Received May 15, 2002; accepted (revised) September 13, 2002 |
| |
| Keywords: | . Endocrine disrupters Apigenin Metabolites HPLC Column switching Electrospray. |
| 本文献已被 SpringerLink 等数据库收录！ |
|
