|
|||||
|
|
Enantioselective C--C bond formation to sulfonylimines through use of the 2-pyridinesulfonyl group as a novel stereocontroller |
|
| Authors: | Nakamura Shuichi Nakashima Hiroki Sugimoto Hideki Sano Hideaki Hattori Masataka Shibata Norio Toru Takeshi |
| Affiliation: | Department of Applied Chemistry, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555, Japan. snakamur@nitech.ac.jp |
| Abstract: | Enantioselective C--C bond formation to 2-pyridinesulfonylimines afforded products with good enantioselectivity. Dynamic induction of chirality on the sulfur by coordination of a chiral Lewis acid to the pyridine nitrogen and one of the prochiral sulfonyl oxygens induces enantioselectivity. Since the 2-pyridinesulfonyl group can easily be removed after the reaction, it acts not only as an activating group but also as an efficient stereocontroller. |
| Keywords: | asymmetric synthesis Grignard reactions Mannich‐type reactions stereocontroller Strecker‐type reaction |
| 本文献已被 PubMed 等数据库收录！ | |