基于磁共振成像的人脑图谱构建方法研究进展

基于磁共振成像的脑图谱构建对于脑与认知科学的研究非常重要，借助脑图谱，研究者可以精确地分析比较不同的脑影像数据，然而目前尚没有比较统一的标准脑图谱.本文针对基于磁共振成像的脑图谱构建方法进行概述，首先介绍了人脑图谱构建的发展进程，阐述脑图谱构建中需解决的技术问题及其局限性；然后着重描述了构建脑图谱的基本方法；最后论述了应用脑图谱进行精确定量分析的统计学方法，包括基于体素的形态学测量分析法和基于纤维束示踪的空间统计分析法，并较深入地比较了两种方法的差异和近期研究进展.通过分析目前研究现状，本文总结了脑图谱构建研究中的主要方法及不足，并就该领域未来的研究进展进行了展望.

Advances in Construction of Human Brain Atlases from Magnetic Resonance Images

Human brain atlases constructed from magnetic resonance images are extremely important for brain and cognition researches. With these atlases or brain maps, researchers can accurately analyze and compare different brain images. In this paper, the research progresses of brain atlas construction from magnetic resonance images are reviewed. Firstly, the development of human brain atlases from magnetic resonance images was introduced, including the technical skills required as well as the limitations. Then the basic technical methods for atlas construction are described. Finally, the statistical methods used for quantitative atlas-based analysis were reviewed, such as voxel-based morphometry and tract-based spatial statistical analysis. By analyzing the current research status, the limitations in the existing methodology and the trend of future development were put forward.