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| 新型含2-取代-1,3-噻唑烷环的噻唑酰胺类化合物的合成与生物活性研究 | |
| 引用本文： | 戴红,刘建兵,苗文科,吴珊珊,张欣,王婷婷,方建新. 新型含2-取代-1,3-噻唑烷环的噻唑酰胺类化合物的合成与生物活性研究[J]. 有机化学, 2011, 31(11) |
| 作者姓名： | 戴红 刘建兵 苗文科 吴珊珊 张欣 王婷婷 方建新 |
| 作者单位： | 1. 南开大学元素有机化学国家重点实验室 天津300071;南通大学化学化工学院 南通226019 2. 南开大学元素有机化学国家重点实验室 天津300071 |
| 基金项目： | 国家自然科学基金，南通市科技计划，南通大学自然科学基金 |
| 摘 要： | 为了寻找新的含噻唑杂环的先导化合物,利用¨(2-氰基亚胺基-1,3-噻唑烷-3-基)甲基]-2-氨基噻唑与取代苯甲酰氯(或乙酰氯)在吡啶存在下发生缩合反应,合成了19个新型含2-取代-1,3-噻唑烷环的噻唑酰胺类化合物4.经1HNMR和元素分析对目标化合物的结构进行了表征,经MS进一步证实了化合物4s的结构,并通过X射线单晶衍射分析测定了化合物4a的晶体结构.对所合成的目标化合物进行了生物活性测试,部分化合物表现出一定的杀菌和植物生长调节活性. |
| 关 键 词： | 2-取代-1,3-噻唑烷 噻唑 酰胺 合成 生物活性 |
Synthesis and Bioactivities of Novel Thiazole Amide Derivatives Containing a 2-Substituted-1,3-thiazolidine Ring |
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| Dai, Hong,Liu, Jianbing,Miao, Wenke,Wu, Shanshan,Zhang, Xin,Wang, Tingting,Fang, Jianxin. Synthesis and Bioactivities of Novel Thiazole Amide Derivatives Containing a 2-Substituted-1,3-thiazolidine Ring[J]. Chinese Journal of Organic Chemistry, 2011, 31(11) | |
| Authors: | Dai Hong Liu Jianbing Miao Wenke Wu Shanshan Zhang Xin Wang Tingting Fang Jianxin |
| Affiliation: | Dai,Hong a,b Liu,Jianbinga Miao,Wenkea Wu,Shanshana Zhang,Xina Wang,Tingtinga Fang,Jianxin a(a State Key Laboratory of Elemento-organic Chemistry,Nankai University,Tianjin 300071)(b College of Chemistry and Chemical Engineering,Nantong University,Nantong 226019) |
| Abstract: | In order to find novel thiazole-heterocycle lead compounds,nineteen new thiazole amides 4 containing 2-substituted-1,3-thiazolidine were synthesized from a condensation reaction of 2-cyanoimino-3-(2-aminothiazol-4-ylmethyl)thiazolidine with substituted benzoyl chlorides(or acetyl chloride).The struc-tures of these compounds were confirmed by 1H NMR spectra and elemental analysis.The structure of 4s was further characterized by MS technique.The structure of 4a was also determined by X-ray diffraction analysi... |
| Keywords: | 2-substituted-1 3-thiazolidine thiazole amide synthesis bioactivity |
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