1. Department of Microbiology and Immunology, University of Western Ontario, London, Ontario N6A 5C1, Canada;2. Centre for Human Immunology, University of Western Ontario, London, Ontario N6A 5C1, Canada;3. Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
Abstract:
Highlights? Staphylococcus aureus SbnG is discovered to be an iron-regulated citrate synthase ? SbnG provides citrate for synthesis of the citrate siderophore staphyloferrin B ? Staphyloferrin B can be synthesized in vitro using purified enzymes ? SbnG inhibitors identified