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Discovery of an Iron-Regulated Citrate Synthase in Staphylococcus aureus
Authors:Johnson Cheung,Michael   E.P. Murphy,David   E. Heinrichs
Affiliation:1. Department of Microbiology and Immunology, University of Western Ontario, London, Ontario N6A 5C1, Canada;2. Centre for Human Immunology, University of Western Ontario, London, Ontario N6A 5C1, Canada;3. Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
Abstract:
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  • Highlights? Staphylococcus aureus SbnG is discovered to be an iron-regulated citrate synthase ? SbnG provides citrate for synthesis of the citrate siderophore staphyloferrin B ? Staphyloferrin B can be synthesized in vitro using purified enzymes ? SbnG inhibitors identified
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