Synthesis,Characterization and Antitumor Activities of Co,Ni, Cu,Zn Complexes with 1,4,7,10-tetrakis(4-nitrobenzyl)-1,4,7,10 tetraazacyclododecane Macrocyclic Ligand

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Synthesis, Characterization and Antitumor Activities of Co, Ni, Cu, Zn Complexes with 1,4,7,10- tetrakis (4- nitrobenzyl )- 1,4,7,10- tetraazacyclododecane Macrocyclic Ligand

New tetraazamacrocyclic ligand with 1, 4, 7, 10-tetrakis (4-nitrobenzyl) pendent groups (C36H40N8O8, Mr= 712.76) crystallized in the monoclinic system, P21/n space group with unit cell parameters: a=7. 834(2), b=22. 902(6), c =10. 147(3)A, β=106.53(2)°, V=1745(1)A3, Z=2, Dc=1. 356 g/cm3, λ(MoKa)=0. 71069 A ; μ=0. 92cm-1, F(000)=752, T=296K. The final R and Rw values are 0.065 and 0.066, respectively. The Cu( Ⅱ ), Ni( Ⅱ ), Co( Ⅱ ), Zn( Ⅱ ) complexes with this new ligand have been synthesized and characterized by elemental analyses, IR, UV, ESI-MS and molar conductance. The macrocyclic ligand molecular structure is centrosymmetrical. All complexes are in accordance with the general forN8O8). The central metal ions coordinate to four nitrogen atoms of azamacrocycle and two oxygen atoms of one nitrate ion. Preliminary pharmacological tests against P-388and A-549 tumor cell lines showed that all these complexes had considerable activities in vitro.