Rhodium(I)-catalyzed carboxylation of aryl- and alkenylboronic esters with CO2 |
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Authors: | Ukai Kazutoshi Aoki Masao Takaya Jun Iwasawa Nobuharu |
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Institution: | Department of Chemistry, Tokyo Institute of Technology, O-Okayama, Meguro-ku, Tokyo 152-8551, Japan. |
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Abstract: | When the esters of arylboronic acids with 2,2-dimethylpropan-1,3-diol were treated with a catalytic amount of Rh(OH)(cod)]2 in the presence of 1,3-bis(diphenylphosphino)propane and CsF in dioxane at 60 degrees C under carbon dioxide atmosphere, the benzoic acid derivatives were obtained in good yields. Reactions of alkenylboronic esters also proceeded under similar conditions to give alpha,beta-unsaturated carboxylic acids. As these boronic esters are now easily available through coupling or direct borylation reactions, this method would be a useful method for the preparation of various functionalized aryl- and alkenyl-carboxylic acids. |
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