Palladium-assisted organic reactions: VIII. Simple syntheses of 2,3-disubstituted phthalimidines |
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| Affiliation: | 1. Anatomy, Department of Medicine, University of Fribourg, Route Albert-Gockel 1, Fribourg CH-1700, Switzerland;2. Institute of Biochemistry, Biological Research Center of the Hungarian Academy of Sciences, Temesvári krt. 62, Szeged H-6701, Hungary;3. Department of Surgery, Center for Prostate Disease Research, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA;5. Institute of Chemistry, Faculty of Material Science and Engineering, University of Miskolc, H-3515, Hungary |
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| Abstract: | ![]()
Electron-poor alkenes such as alkyl acrylates have been found to insert into the aromatic carbon—palladium bond in orthobromobenzamides under the conditions of the Heck reaction. For primary and secondary benzamides a further palladium-catalysed reaction occurs to yield 3-substituted, or 2,3-disubstituted phthalimidines. |
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