Natural Products in Preventing Tumor Drug Resistance and Related Signaling Pathways |
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| Authors: | Chuansheng Yang Zhikai Mai Can Liu Shuanghong Yin Yantao Cai Chenglai Xia |
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| Affiliation: | 1.Department of Head-Neck and Breast Surgery, Yuebei People’s Hospital of Shantou University, Shaoguan 512027, China;2.Affiliated Foshan Maternity and Chlid Healthcare Hospital, Southern Medical University, Foshan 528000, China; (Z.M.); (C.L.); (S.Y.);3.School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China |
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| Abstract: | ![]()
Drug resistance is still an obstacle in cancer therapy, leading to the failure of tumor treatment. The emergence of tumor drug resistance has always been a main concern of oncologists. Therefore, overcoming tumor drug resistance and looking for new strategies for tumor treatment is a major focus in the field of tumor research. Natural products serve as effective substances against drug resistance because of their diverse chemical structures and pharmacological effects. We reviewed the signaling pathways involved in the development of tumor drug resistance, including Epidermal growth factor receptor (EGFR), Renin-angiotensin system (Ras), Phosphatidylinositol-3-kinase/protein kinase B (PI3K/Akt), Wnt, Notch, Transforming growth factor-beta (TGF-β), and their specific signaling pathway inhibitors derived from natural products. This can provide new ideas for the prevention of drug resistance in cancer therapy. |
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| Keywords: | tumor drug resistance signaling pathway mechanism |
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