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Voltammetric Determination of Folic Acid Using a Graphite Paste Electrode |
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| Authors: | Eliane Gonçalves de Araújo Nedja Suely Fernandes Lilian Grace da Silva Solon Cícero Flavio Soares Aragão Carlos A. Martinez‐Huitle |
| Affiliation: | 1. Federal University of Rio Grande do Norte, Institute of Chemistry, Lagoa Nova – CEP 59.072‐970 – Natal, RN, Brazil;2. Federal University of Rio Grande do Norte, Department of Pharmacy, Av. Geral Cordeiro de Faria s/n, Petrópolis – CEP 59.010‐180 – Natal, RN, Brazil |
| Abstract: | A simple differential pulse voltammetric method based on a graphite paste electrode (GPE) was developed for the quantitative determination of folic acid (FA) in tablets. The electrode exhibits a clear improvement of the current response. A linear response in the electroanalytical approach exists from 4.97×10?6 to 2.94×10?5 mol L?1 with a limit of detection of about 2.67×10?6 mol L?1 in KCl solutions. The developed procedure was tested by recovery studies and compared with spectrophotometric and chromatographic methods. The results are described and discussed in the light of existing literature. |
| Keywords: | Folic acid Voltammetry techniques Graphite paste electrode |