New polyhydroxylated pyrrolidines derived from enantiopure 3,6-dihydro-2H-1,2-oxazines |
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| Authors: | Pulz Robert Al-Harrasi Ahmed Reissig Hans-Ulrich |
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| Affiliation: | Institut für Chemie - Organische Chemie, Freie Universit?t Berlin, Takustrasse 3, D-14195 Berlin, Germany. |
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| Abstract: | [reaction: see text] Diastereoselective hydroborations of enantiopure 3,6-dihydro-2H-1,2-oxazines led to dihydroxy-substituted 1,2-oxazines. Samarium diiodide-induced N-O bond cleavage generated 1,4-amino alcohols which were recyclized to polyhydroxylated pyrrolidines which are potential glycosidase inhibitors. |
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