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Novel synthesis of L-ribose from D-mannono-1,4-lactone
Authors:Takahashi Hideyo  Iwai Yoshinori  Hitomi Yuko  Ikegami Shiro
Affiliation:Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, Kanagawa 199-0195, Japan.
Abstract:
[reaction: see text] D-Mannono-1,4-lactone was efficiently converted into L-ribose in eight steps. A key step of this synthesis is the cyclization of a gamma-hydroxyalkoxamate under Mitsunobu conditions. It is noteworthy that the O-alkylation product was obtained in 94% yield and that none of the N-alkylation product was detected in this cyclization.
Keywords:
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