| N-取代苯基-2-取代-1,3-噻唑烷-3-甲酰胺的合成、结构及生物活性 |
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| 引用本文： | 翁建全,沈德隆,谭成侠,欧晓明.N-取代苯基-2-取代-1,3-噻唑烷-3-甲酰胺的合成、结构及生物活性[J].有机化学,2006,26(8):1106-1110. |
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| 作者姓名： | 翁建全 沈德隆 谭成侠 欧晓明 |
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| 作者单位： | 1. 浙江工业大学化学工程与材料学院,杭州,310032
2. 国家南方农药创制中心湖南基地生测部,长沙,410007 |
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| 基金项目： | 浙江省教育厅基金(No.20030145)资助项目. |
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| 摘 要： | 为了寻找新的含噻唑杂环的先导化合物, 利用2-取代-1,3-噻唑烷与取代苯基异氰酸酯在三乙胺催化下发生偶合反应, 合成了17个N-取代苯基-2-取代-1,3-噻唑烷-3-甲酰胺化合物3, 并利用1H NMR, IR, MS和元素分析对其结构进行了表征. 用X-ray单晶衍射测定了N-苯基-2-氧代-1,3-噻唑烷-3-甲酰胺(3a)的晶体结构. 初步生物活性试验结果表明, 在试验浓度下部分目标化合物具有一定的杀菌和杀虫活性.
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| 关 键 词： | 2-取代-1 3-噻唑烷 取代苯基异氰酸酯 合成 结构 生物活性 |
| 收稿时间： | 11 17 2005 12:00AM |
| 修稿时间： | 02 16 2006 12:00AM |
Synthesis, Structure and Biological Activities of N-Arylaminocarbonyl-2-oxo/thio-thiazolidine |
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| WENG, Jian-Quan,SHEN, De-Long,TAN, Cheng-Xia,OU, Xiao-Ming.Synthesis, Structure and Biological Activities of N-Arylaminocarbonyl-2-oxo/thio-thiazolidine[J].Chinese Journal of Organic Chemistry,2006,26(8):1106-1110. |
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| Authors: | WENG Jian-Quan SHEN De-Long TAN Cheng-Xia OU Xiao-Ming |
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| Institution: | 1. College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310032;2. Bioassay Department, Hunan Branch of National Southern Pesticide Research Centre, Changsha 410007 |
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| Abstract: | In order to find new thiazole-heterocycle lead compounds, seventeen N-arylaminocarbonyl-2- oxo/thio-thiazolidine derivatives were synthesized from a coupling reaction of 2-oxo/thio-thiazolidine and aryl isocyanates catalyzed by Et3N. Their structures were confirmed by 1H NMR, IR, MS spectra and ele- mental analysis. The crystal structure of N-anilinocarbonyl-2-oxothiazolidine was determined by X-ray dif- fraction analysis. The preliminary bioassay showed that some of them exhibited certain fungicidal and insec- ticidal activities. |
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| Keywords: | 2-oxo/thio-thiazolidine substituted phenyl isocyanate synthesis structure biological activity |
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