| 氯雷他定的合成 |
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| 引用本文： | 司马利锋,王玥,林艳,李阳,陈立功.氯雷他定的合成[J].化学通报,2012(4):353-356. |
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| 作者姓名： | 司马利锋 王玥 林艳 李阳 陈立功 |
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| 作者单位： | 天津大学化工学院 |
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| 摘 要： | 以N-甲基-4-哌啶酮和8-氯-10,11-二氢-4-氮杂-5H-二苯并a,d]-5-环庚酮为原料,经McMurry反应得到8-氯-6,11-二氢-11-(1-甲基-4-哌啶烯基)-5H-苯并5,6]庚环1,2-b]吡啶,收率为83.9%,最后与氯甲酸乙酯反应得到氯雷他定,总收率为35.7%。对McMurry反应过程中产生的副产物3、4进行了分离、表征。
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| 关 键 词： | 氯雷他定 McMurry反应 抗组胺 |
Synthesis of Loratadine |
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| Sima Lifeng,Wang Yue,Lin Yan,Li Yang,Chen Ligong.Synthesis of Loratadine[J].Chemistry,2012(4):353-356. |
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| Authors: | Sima Lifeng Wang Yue Lin Yan Li Yang Chen Ligong |
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| Institution: | (School of Chemical Engineering and Technology,Tianjin University,Tianjin 300072) |
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| Abstract: | The McMurry reaction of N-methyl-4-piperidone with 8-Chloro-10,11-dihydro-4-aza-5H-dibenzocyclohepten-5-one afforded 8-Chloro-6,11-dihydro-11-(1-methyl-pipridin-4-ylene)-5H-benzo-cyclohepta pyridine in 83.9% yield,and subsequently was treated with ethyl chlorocarbonate to give Loratadine in a overall yield of 35.7%.The by-products of 3 and 4 generated in McMurry reaction were separated and characterized. |
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| Keywords: | Loratadine McMurry reaction Antihistamine |
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