| Studies on the cyclization reaction of D-aspartic acid |
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| 作者姓名： | Yu Chuan Li Si Ping Pang Yong Zhong Yu |
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| 作者单位： | Yu Chuan Li，Si Ping Pang，Yong Zhong Yu School of Life Science and Technology，Beijing Institute of Technology，Beijing 100083，China |
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| 摘 要： | The cyclization reaction of D-aspartic acid was studied, the carboxyl groups of D-aspartic acid were protected by benzyl alcohol to give compound D-dibenzyl aspartate. Then (4R)-benzyl azetidine-2-one-4-carboxylate and meso-3,6-disubstituted piperazine- 2,5-diones were synthesized via intramolecular cyclization and intermolecular cyclization of D-dibenzyl aspartate, respectively, and their structures were confirmed by 1H NMR and MS. Both cyclization reaction conditions were also investigated in detail.
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| 关 键 词： | D-天冬氨酸 环化反应 羧基保护 吖丁啶-2-酮 合成 |
| 收稿时间： | 2006-12-08 |
Studies on the cyclization reaction of D-aspartic acid |
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| Yu Chuan Li Si Ping Pang Yong Zhong Yu.Studies on the cyclization reaction of D-aspartic acid[J].Chinese Chemical Letters,2007,18(5):516-518. |
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| Authors: | Yu Chuan Li Si Ping Pang Yong Zhong Yu |
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| Institution: | School of Life Science and Technology, Beijing Institute of Technology, Beijing 100083, China |
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| Abstract: | The cyclization reaction of D-aspartic acid was studied, the carboxyl groups of D-aspartic acid were protected by benzyl alcohol to give compound D-dibenzyl aspartate. Then (4R)-benzyl azetidine-2-one-4-carboxylate and meso-3,6-disubstituted piperazine- 2,5-diones were synthesized via intramolecular cyclization and intermolecular cyclization of D-dibenzyl aspartate, respectively, and their structures were confirmed by 1H NMR and MS. Both cyclization reaction conditions were also investigated in detail. |
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| Keywords: | D-Aspartic acid Cyclization reaction Azetidine-2-ones 3 6-Disubstituted piperazine-2 5-diones |
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