Sesquiterpenes produced by Pestalotiopsis microspora HF 12440 isolated from Artocarpus heterophyllus |
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Authors: | Riga Riga Nizar Happyana |
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Institution: | Natural Products Research Group, Organic Chemistry Division, Faculty of Mathematics and Natural Sciences, Bandung Institute of Technology, Indonesia |
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Abstract: | AbstractA drimane-type sesquiterpene, (+)-dendocarbin L (1) together with two bisabolane-type sesquiterpenes, (+)-sydonic acid (2) and (+)-sydowic acid (3) were isolated from the mycelium of Pestalotiopsis microspora HF 12440, an endophytic fungus from the stem of Artocarpus heterophyllus. The structures of all compounds were elucidated using spectroscopic methods and by comparison with the literature. Compound 1 was isolated from the fungi for the first time, compounds 2 and 3 were firstly obtained from this endophytic fungus. Compound 3 showed cytotoxicity (IC50 2.56?μg/mL) against murine leukemia P-388 cells. |
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Keywords: | Artocarpus heterophyllus cytotoxicity Pestalotiopsis microspora sesquiterpene |
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